Sendlein suffered a torn MCL in his left knee in Sunday's loss to the St. Louis Rams. Sendlein, a fifth-year pro from the University of Texas, had started every game over the last four-plus seasons at center for Arizona.
To take his roster spot, the Cardinals signed Scott Wedige off the Cincinnati Bengals practice squad Tuesday.
Wedige originally signed with the Cardinals as an undrafted free agent out of Northern Illinois, but was released on August 31. Before hooking on with Cincinnati, Wedige had spent time on the New York Giants practice squad.